The work is organized into three parts, by theme, delineating a basic understanding of the etiology and the pathophysiology of pancreatic diseases. It is particularly valuable that these areas are described along with many recent discoveries, including new substances in the field of glycoconjugates in the digestive organs. The first part describes a method of purification of glycoconjugates in pancreatic juice and the subsequent analysis of their structure. The second part describes a discovery that formed the basis of our glycotechnology. This includes a novel method for synthesizing tailor-made hyaluronan with the transglycosylation reaction of hyaluronidase, and an innovative method for artificial synthesis of neoproteoglycan with endo-ß-xylosidase. The third part describes the application of 4-methylumbelliferone (4-MU), which we have discovered to be an effective hyaluronic acid synthesis inhibitor for pancreatic cancer treatment. We have observed the significant anti-tumoral activity and substantial effect on metastasis inhibition of 4-MU, which has the potential to help treat pancreatic cancer. This book will be of interest to various researchers. In particular, it will broaden the scope for medical researchers specializing in digestive organs and associated diseases. We sincerely hope that one day this work will open the door to overcoming pancreatic cancer.

Presents the structure on the rare glycoconjugates in the pancreas

Chapter 1: Physiological roles of glycans. - Chapter 2: New and Ingenious Methods Pave the Way for Difficult Studies of the Pancreas.- Chapter 3: Isolation of complex carbohydrates from pancreatic juice obtained after pancreatoduodenectomy.- Chapter 4: Properties of complex carbohydrates in pancreatic juice.- Chapter 5: Significance of complex carbohydrates in pancreatic juice.- Chapter 6: Conclusion.- Chpater 7: Importance of fine structure analysis of proteoglycan glycans and significance of glycan synthesis.- Chapter 8: Glycotechnology as a new biotechnology.- Chapter 9: Development of Synthesis of Glycosaminoglycan Glycans Using Hyaluronidase.- Chapter 10: Total Synthesis of Order-Made Proteoglycans by Glycosylation.- Chapter 11: The Path to Order-Made Total Synthesis of Decorin in the Gastrointestinal Tract.- Chapter 12: Conclusion.- Chapter 13: Discovery of 4-methylumbelliferone, an inhibitor of hyaluronic acid synthesis.- Chapter 14: Presence of HA inextracellular matrix of cancer cells.- Chapter 15: New research development of proteoglycans by inhibition of HA synthesis by MU.- Chapter 16: Development of anti-tumor agents based on the HA synthesis inhibitory activity of MU.- Chapter 17: Emerging Clinical Applications of MU as an Inhibitor of HA Synthesis.- Chapter 18: Conclusion - Toward future clinical applications of MU.