Beschreibung:
Providing valuable insights into the field of RNome in the context of cancer, this book is helpful to students, researchers and clinicians.
1. Section 1. RNome: Evolution and nature.- Chapter. 1.1. RNA world hypothesis.- Chapter.1.2. Various classes of RNAs (coding as well non-coding), their biosynthesis and basic functions.- 2. Section 2. Cellular RNome: Chromatin dynamics.- Chapter. 2.1. Chromatin modifications & transcription.- Chapter. 2.2. RNA modifications and epitranscriptomics.- Chapter. 2.3. Cellular RNome: Contribution of non-coding RNA.- 3. Section 3. Cancer RNome: Evolution and Sustenance.(How is cancer RNome different from RNome of healthy cell? How does the cancer RNome regulate the evolution as well as the sustenance of cancer?).- Chapter. 3.1. Genome instability and mutation.- Chapter. 3.2. Tumor-promoting inflammation.- Chapter. 3.3. DNA methylation addiction.- Chapter. 3.4. Oncoviruses.- Chapter. 3.5. Sustained proliferative signaling.- Chapter. 3.6. Evasion of growth suppressors.- Chapter. 3.7. Replicative immortality.- Chapter. 3.8. Resisting Cell death.- Chapter. 3.9. Invasion and metastasis.- Chapter. 3.10. Angiogenesis induction.-Chapter. 3.11. Deregulated cellular energetics/Molecular sweet tooth.- Chapter. 3.12. Tumor Immune-evasion.- Chapter. 3.13. Cancer stem cells and tumor cell plasticity.- 4. Section 4. Cancer RNome: Therapeutic implications(Translational implications of the cancer RNome). Chapter. 4.1. RNAs as diagnostic/prognostic biomarkers.- Chapter. 4.2. RNAs in cancer therapy & chemo-resistance.