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Induced Pluripotent Stem Cells in Brain Diseases
Understanding the Methods, Epigenetic Basis, and Applications for Regenerative Medicine.
Sofort lieferbar | Lieferzeit: Sofort lieferbar I
ISBN-13:
9789400728165
Veröffentl:
2011
Seiten:
59
Autor:
Vivi M. Heine
Serie:
SpringerBriefs in Neuroscience
eBook Typ:
PDF
eBook Format:
EPUB
Kopierschutz:
1 - PDF Watermark
Sprache:
Englisch
Beschreibung:
The principle goal of regenerative medicine is the restoration of damaged, dysfunctional, or missing cellular tissue, up to and including whole organs. Growing healthy replacement tissue, in vivo or in vitro, plays an important role in anticipated therapies. To generate competent replacement material, scientists confront the fundamental issues of cellular identity and plasticity.
I. Introduction.- II. Cell Reprogramming: A New Era in Regenerative Medicine.- a. Stem Cells.- b. Reprogramming Methods.- c. Measuring Pluripotency, Efficiency, and Identity.- d. Induced Pluripotent Stem Cells versus Embryonic Stem Cells.- III. Understanding Epigenetic Memory is the Key to Successful Reprogramming.- a. Pre-fertilization to Embryo.- b. Epigenetic Control in De-, Re-, and Trans-differentiation.- IV. Prospects for Cell Replacement Therapies for Brain Diseases.- a. Parkinson's Disease.- b. Childhood Brain White Matter Disorders.- V. Conclusions.- VI. Acknowledgement.- VII. References.
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