It is difficult to imagine anyone who has not heard of cancer. This disease can affect families, friends or any one of us at any time in our lives. Every year nearly 3 million Europeans are diagnosed with cancer, leading to around 800,000 deaths per year. These deaths occur not only in aging populations, but also in children and adults who are in the most active period of their lives. This represents a tremendous problem that cannot be ignored by politicians or citizens. Fortunately, there is a constantly growing awareness that although cancer is a problem to be dealt with by clinicians, it should also be the concern of everyone. This volume contains the lectures held at the International Symposium on Cancer "New Trends in Cancer for the 21st Century". Fundamental researchers, politicians and representatives from patient coalitions share here their knowledge and interests as well as their concerns and experiences. Not only do these papers provide state-of-the-art information on cancer, they are also an opportunity to look at the problem from different points of view. It can be encouraging to realise that we are not alone in this fight.

1. Prognostic and Therapeutic Targets in the Ewing¿s Family of Tumors (ProTheTs), P. Picci, K. Scotlandi, M. Serra, and A. Rizzi.- 2. Targeted Therapies in Ewing¿s Sarcoma K. Scotlandi.- 3. The CCN3 Protein and Cancer, B. Perbal.- 4. Ews-Fli1 in Ewing¿s Sarcoma ¿ Real Targets and Collateral Damage, J. Ban, C. Siligan, M. Kreppel, D. Aryee and H. Kovar.- 5. Molecular Karyotyping in Sarcoma Diagnostics and Research, H. Vauhkonen, S. Savola, S. Kaur, M. L. Larramendy and S. Knuutila.- 6. Tubafrost: European Virtual Tumor Tissue Banking, P. H. J. Riegman, M. H. A. Oomen, W. N. M. Dinjens, J. W. Oosterhuis, K. H. Lam, A. Spatz, C. Ratcliffe, K. Knox, R. Mager, D. Kerr, F. Pezzella, B. van Damme, M. van de Vijver, H. van Boven, M. M. Morente, S. Alonso, D. Kerjaschki, J. Pammer, J. A. Lopez-Guerrero, A. Llombart Bosch, A. Carbone, A. Gloghini, I. Teodorovic, M. Isabelle, A. Passioukov, S. Lejeune, P. Therasse and E-B. van Veen.- 7. Virtual Microscopy in Virtual Tumor Banking, M. Isabelle, I. Teodorovic, J. W. Oosterhuis, P. H. J. Riegman and the TuBaFrost Consortium.- 8. Harmonizing Cancer Control in Europe, U. Ringborg.- 9. The Diagnosis of Cancer: 'From H&E to Molecular Diagnosis and Back', J. Costa.- 10. From Morphological to Molecular Diagnosis of Soft Tissue Tumors, M. Miettinen.- 11. Prediction of Response to Neoadjuvant Chemotherapy in Carcinomas of the Upper Gastrointestinal Tract H. Höfler, R. Langer, K. Ott and G. Keller.- 12. Integrating the Diagnosis of Childhood Malignancies, D. López-Terrada.- 13. Preclinical Models for Cell Cycle-Targeted Therapies, M. Malumbres.- 14. WWOX, a Chromosomal Fragile Site Gene and its Role in Cancer, Ramos D. and Aldaz C. M.- 15. From Genome to Proteome in Tumor Profiling, J. K. Habermann, U. J. Roblick, M. Upender, T. Ried and G. Auer.- 16. Effect of Hypoxia on the Tumor Phenotype: the Neuroblastoma and Breast Cancer Models, L. Holmquist, T. Löfstedt and S. Påhlman.- 17. Methylation Patterns andChemosensitivity in NSCLC, J. L. Ramirez, M. F. Salazar, J. Gupta, J. M. Sánchez, M. Tarón, M. Sánchez-Ronco, Vicente Alberola and R. de las Peñas.- 18. Pharmacogenomics and Colorectal Cancer, H. J. Lenz.- 19. Development of Pharmacogenomic Predictors for Preoperative Chemotherapy of Breast Cancer, L. Pusztai.- 20. Vascular Endothelial Growth Factor Inhibitors in Colon Cancer, E. Díaz-Rubio.- 21. Molecular Imaging of Cancer Using PET and SPECT, A. Kjær, B. Celda, D. Monleón, M. C. Martínez-Bisbal, V. Esteve, B. Martínez-Granados, E. Piñero, R. Ferrer, J. Piquer, L. Martí-Bonmatí and J. Cervera.- 23. From Linac to Tomotherapy: New Possibilities for Cure? G. Storme, D. Verellen, G. Soete, N. Linthout, J. Van de Steene, M. Voordeckers, V. Vinh-Hung, K. Tournel, and D. Van den Berge.- 24. Targeting mTOR for Cancer Treatment, B. Rubio-Viqueira and M. Hidalgo.- 25. Dual/Pan-Her Tyrosine Kinase Inhibitors (TKI): Focus in Breast Cancer, J. Albanell.- 26. Anti-Tumor Associated Antigens IGGS. Dual Positive and Negative Potential Effects For Cancer Therapy, E. Barberá-Guillem and J. W. Sampsel.- 27. Synergistic Molecular Mechanisms in Hormone Sensitive Breast Cancer, A. Llombart Cussac.- Contributors.- Index