The book complements the author¿s previous monographs (Generalized Boltzmann Physical Kinetics [Elsevier, 2004], Unified Non-Local Theory of Transport Processes [Elsevier, 2015] and Unified Non-Local Relativistic Theory of Transport Processes [Elsevier, 2016], which are devoted to non-local physics. Key Features: Dark matter is only an artifact of local physics. Dark matter does not exist ¿ Transport processes in Physical Vacuum, Michelson - Morley experiment and the theory of Physical Vacuum are considered ¿ Big Bang is a burst of Physical Vacuum (PV) ¿ The non-local theory of the Universe expanding is created ¿ The creation and motion of the Hubble¿s boxes is investigated ¿ Dark Energy is energy of PV which leads to the effect of anti-gravitation ¿ The PV boxes as an analogue of the Hubble¿s boxes are introduced ¿ The theory of the PV engines is developed ¿ The stability of Black Holes is investigated ¿ All results are obtained from the first principles of physics. Physical Reality contains Matter, Fields and Physical Vacuum.