Radiation safety and risk management, a critical issue in the nuclear age, is an ongoing concern in the field of radiation health risk sciences. It is the particular mission and task of the Nagasaki University Global COE program to explore human health risks from radiation on a global scale and to come up with measures for overcoming its negative legacies. Ionizing radiation is a well-documented human cancer risk factor, and long-term health consequences in individuals exposed at a young age to such events as the Hiroshima and Nagasaki atomic bombing are now being followed up. Unique and comprehensive, this book introduces updated radiation health-related issues, including the proper collection and analysis of biological samples, cancer research, psychological effects, fair disclosure, and the effects of low-dose exposure as they apply to future public health policy. Also addressed is the need for emergency radiation medicine in case of accidents.

Unique and comprehensive

Overview of the Global COE ProgramGlobal Strategic Center for Radiation Health Risk Control

Overview of the Lectures
Discussion on Points of Radiation Safety and the Scope of The University of Tokyo Global COE Program
Network System for Radiation Emergency Medicine in Japan and the Role of Hiroshima University
Non-DNA-Targeted Effects and Low-Dose Radiation Risk
Update from the Chernobyl Tissue Bank: Effect of Latency on Different Types of Thyroid Cancer Post-Chernobyl
Current Risk Estimate of Radiation-Related Cancer and Our Insight into the Future

Atomic Bomb Disease Medicine
Introduction of Atomic Bomb Disease Medical Research in Global COE Program
The Offspring of Atomic Bomb Survivors: Cancer and Non-Cancer Mortality and Cancer Incidence
Ischemic Heart Disease Among Atomic Bomb Survivors: Possible Mechanism(s) Linking Ischemic Heart Disease and Radiation Exposure
Leukemia, Lymphoma, and Multiple Myeloma Incidence in the LSS Cohort: 1950?2001
Follow-Up Study of 78 Healthy Exposed Atomic Bomb Survivors for 35 Years in Hiroshima, with Special Reference to Multiple Cancers

International Radiation Health Sciences
Research Activities and Projects Within a Framework of International Radiation Health Sciences Research
Age and Prognosis: Do Adjuvant Therapies Influence the Real Prognosis?
Mortality of the Chernobyl Emergency Workers: Analysis of Dose Response by Cohort Studies Covering Follow-Up Period of 1992?2006
Twenty Years After Chernobyl: Implications for Radiation Health Risk Control
Fallout Exposure of the Population and Thyroid Nodular Diseases

Radiation Basic Life Sciences, Part 1
Higher-Order Chromatin Structure and Nontargeted Effects
p53 Dependency of Delayed and Untargeted Recombination in Mouse Embryos Fertilized by Irradiated Sperm
The Yin and Yang of Low-Dose Radiobiology
Induction and Persistence of Cytogenetic Damage in Mouse Splenocytes Following Whole-Body X-Irradiation Analysed by Fluorescence In Situ Hybridisation. V. Heterogeneity/Chromosome Specificity

Cancer Research
Molecular Understanding of RET/PTC-Mediated Thyroid Carcinogenesis
Molecular Prediction of Therapeutic Response and Adverse Effect of Chemotherapy in Breast Cancer
Multiple Roles of NBS1 for Genotoxic and Nongenotoxic Stresses

Radiation Basic Life Sciences, Part 2
The DNA Damage Response in Nontargeted Cells
The Role of Telomere Dysfunction in Driving Genomic Instability
Secretory Clusterin Is a Marker of Tumor Progression Regulated by IGF-1 and Wnt Signaling Pathways
Target of Radiation Carcinogenesis Is Protein: Becoming Triploid Is Proximate Cause of Cell Transformation
Adult Stem Cells, the Barker Hypothesis, Epigenetic Events, and Low-Level Radiation Effects
Combined Effect of Ionizing Radiation and N-Ethyl-N-Nitrosourea on Mutation Induction and Lymphoma Development
g-Ray-Induced Mouse Thymic Lymphomas: Bcl11b Inactivation and Prelymphoma Cells

Radiation Risk Management
Framework of Radiation Safety Management in Japan: Laws, Administrative Agencies, and Supporting Associations
Background Radiation Dose to the Population Around the Kudankulam Nuclear Power Plant
International Cooperation in Radiation Emergency Medical Preparedness: Establishment of a Medical Network in Asia

Disaster and Mental Health
Long-Term Biopsychosocial Consequences of Disaster: Focuson Atomic Bomb Survivors
Health Status of Children Exposed to the Chernobyl Accident In Utero: Observations in 1989?2003 and the Implications for Prioritizing Prophylactic Programs
Psychological Consequences More Than Half a Century After the Nagasaki Atomic Bombing

Radiation and