Business incubation is that place where start up entrepreneurs can thrive when they are surrounded by fellow entrepreneurs to get more effective training, guidance, required motivation and confidence building measures to form enterprises from entrepreneurs and practicing professional business development service providers. The research study follows the concept of comprehensive incubation system framework to understand the South Korean successful incubation process and simultaneously designing a successful approach for Nepal, which can be an effective model of Business Incubation Center development. Incubator program in the service package designed for Nepal, explains the inputs that come from community to incubator startups to meet the challenges during their graduation period and let off in the community as growing companies such as superstars, small medium enterprises, talented entrepreneurs for spin-off companies, and support for R&D of large companies having innovative ideas. Lastly, the key is not to have a fancy framework but to design a valuable service program for clients for business start ups supported by incubation services in Nepal.