A comprehensive one-source guide to the most current information on red blood cell formation and the action of recombinant human erythropoietins. Topics covered include: erythropoiesis, recombinant protein discovery and production, and treatment of patients with anemia. The newest theories in erythropoiesis (receptors, signaling), manufacturing, new formulations, and clinical research are discussed. The text is ideal for researchers and clinical investigators in academia, biotechnology, and pharmaceutical companies, as well as clinical research associates, clinical monitors, and physician investigators. This softcover volume is an unchanged second printing of the hardcover edition published in 2003.

"This volume is a one-source guide to the most current information about red blood cell formation and the action of recombinant human erythropoietins. Topics in the fields of erythropoiesis, recombinant protein discovery and production, and treatment of patients with anemia will be covered. The newest theories in erythropoiesis (receptors, signaling), manufacturing, new formulations, and clinical research are discussed. It is of interest to researchers and clinical investigators in academia and biotechnology and pharmaceutical companies, to clinical research associates, clinical monitors, and physician investigators. This softcover volume is an unchanged second printing of the hardcover edition published in 2003. TOC:Background and basic science.- Erythropoiesis: an overview. Studies of erythropoiesis and the discovery and cloning of recombinant human erythropoietin. Structural basis for the signal transduction of erythropoietin. Molecular biology of the erythropoietin receptor in hematopoietic and non-hematopoietic tissues. Erythropoietin receptor signaling processes. Clinical pharmacokinetic properties of rHuEPO: a review. Biology of erythropoietin. Commercial production of recombinant erythropoietins.- Clinical use of recombinant erythropoietins.- Use of recombinant erythropoietins in the setting of renal disease. Erythropoietic therapy in the practice of oncology. Use of recombinant erythropoietins for the treatment of anemia of chronic disease. Use of erythropoietins in the surgical setting. Abuse of recombinant erythropoietins by athletes. Antibodies to endogenous and recombinant erythropoietin. New molecules and formulations of recombinant human erythropoietin.- Glossary of terms and abbreviations.- Index."

Background and basic science.- Erythropoiesis: an overview.- Studies of erythropoiesis and the discovery and cloning of recombinant human erythropoietin.- Structural basis for the signal transduction of erythropoietin.- Molecular biology of the erythropoietin receptor in hematopoietic and non-hematopoietic tissues.- Erythropoietin receptor signaling processes.- Clinical pharmacokinetic properties of rHuEPO: a review.- Biology of erythropoietin.- Commercial production of recombinant erythropoietins.- Clinical use of recombinant erythropoietins.- Use of recombinant erythropoietins in the setting of renal disease.- Erythropoietic therapy in the practice of oncology.- Use of recombinant erythropoietins for the treatment of anemia of chronic disease.- Use of erythropoietins in the surgical setting.- Abuse of recombinant erythropoietins by athletes.- Antibodies to endogenous and recombinant erythropoietin.- New molecules and formulations of recombinant human erythropoietin.