Mycobacterium tuberculosis is one of the most notorious pathogens on earth, causing the death of approximately 1.5 million people annually. A major problem in the fight against tuberculosis is the emergence of strains that have acquired resistance to all available antibiotics. One key to the success of M. tuberculosis as a pathogen is its ability to circumvent host immune responses at different levels. This is not only a result of the special makeup of M. tuberculosis in terms of genetic diversity and DNA metabolism and its possession of specialized secretion systems, but also of its ability to hijack the host¿s innate immune defence mechanisms.In this volume, researchers from different disciplines provide a topical overview of the diverse mechanisms that contribute to the virulence of M. tuberculosis, ranging from their genetic, metabolic and molecular makeup, as well as the complex strategies these bacteria utilize to escape immune destruction within infected hosts.

A stimulus for the further exploration of the intricate biology of Mycobacterium tuberculosis and its interaction with the host

Genetic Diversity inMycobacterium tuberculosis.DNA Metabolism in Mycobacterial Pathogenesis.- Molecular Biology of Drug Resistance inMycobacterium tuberculosis.Antimicrobial Efflux Pumps andMycobacterium tuberculosisDrug Tolerance: Evolutionary Considerations.- Getting Across the Cell Envelope: Mycobacterial Protein Secretion.- A Single-Cell Perspective on Non-Growing but Metabolically Active (NGMA) Bacteria.Mycobacterium tuberculosisMetabolism and Host Interaction: Mysteries and Paradoxes.- Surviving the Macrophage: Tools and Tricks Employed byMycobacterium tuberculosis.Host-Pathogen Interactions DuringMycobacterium tuberculosisInfections.