This text is designed for a first course in biological mass transport, and the material in it is presented at a level that is appropriate to advanced undergraduates or early graduate level students. Its orientation is somewhat more physical and mathematical than a biology or standard physiology text, reflecting its origins in a transport course that I teach to undergraduate (and occasional graduate) biomedical engineering students in the Whiting School of Engineering at Johns Hopkins. The audience for my cours- and presumably for this text - also includes chemical engineering undergraduates concentrating in biotechnology, and graduate students in biophysics. The organization of this book differs from most texts that at­ tempt to present an engineering approach to biological transport. What distinguishes biological transport from other mass transfer processes is the fact that biological transport is biological. Thus, we do not start with the engineering principles of mass transport (which are well presented elsewhere) and then seek biological ap­ plications of these principles; rather, we begin with the biological processes themselves, and then develop the tools that are needed to describe them. As a result, more physiology is presented in this text than is often found in books dealing with engineering applica­ tions in the life sciences.

1 Equilibrium Thermodynamics.- 1.1 Chemical Potentials and Activities.- 1.2 Ion Equilibrium Across Membranes.- 1.3 Chemical Equilibrium.- 2 Free Diffusion.- 2.1 Free Diffusion of Nonelectrolytes.- 2.2 Free Diffusion of Electrolytes.- 3 Facilitated Diffusion.- 3.1 Mechanisms of Channels and Carriers.- 3.2 Kinetics of Facilitated Transport.- 3.3 Inhibition of Carrier Transport.- 4 Active Transport.- 4.1 Active Transport: General Considerations.- 4.2 Mechanisms of Active Transport.- 4.3 Kinetics of Active Transport.- 5 Nonequilibrium Thermodynamics.- 5.1 The Basic Phenomenological Equations.- 5.2 Nonequilibrium Thermodynamic Description of Passive Transport.- 5.3 Nonequilibrium Thermodynamic Description of Active Transport.- 5.4 Limitations of Nonequilibrium Thermodynamics.- 6 Models of Transport Across Cell Membranes.- 6.1 Composition and Structure of Cell Membranes.- 6.2 Transport Across the Lipid Bilayer of Cell Membranes.- 6.3 Models of Transport Through Pores.- 6.4 Electrical Analogs.- 7 Single Cells.- 7.1 Erythrocytes.- 7.2 Nerve.- 7.3 Muscle.- 8 Epithelial Transport.- 8.1 Organization of Epithelial Tissue and Some Consequences.- 8.2 Example Epithelia.- 8.3 Regulation of Epithelial Transport.- 9 Gas Transport.- 9.1 Overview of the Gas Transport Process.- 9.2 Models of Capillary Perfusion.- References.