The 1st Edition of Histopathology of Non-Hodgkin's Lymphomas, written in col­ laboration with Professor H. STEIN and published in 1981, was received well and is now out of print. In the meantime, there has been an explosion of data that not only have made the definitions of various entities more precise but, above all, have confirmed the main entities originally delineated in the Kiel classification. The development of monoclonal antibodies and molecular cytogenetics has also made it possible to identify T-cell lymphomas more accurately. For example, many of the malignant lymphomas that were previously considered to be unclas­ sifiable can now be included in a classification scheme that places the T-cell lymphomas alongside of the list of B-cell lymphomas. In 1988 the European Lymphoma Club published an "updated Kiel classification" (STANSFELD et al. 1988) based on this new knowledge. It includes a number of previously undefined types of T-cell lymphoma. Studies done in Japan (T. SUCH! et al.) and China (L. Y Tu) have contributed to the understanding of these lymphoma types.

1 The Diagnosis of Lymphoma.- 1.1 Practical Tips.- 1.2 Immunohistochemistry and Molecular Genetics as Ancillary Diagnostic Measures.- 2 The Kiel Classification.- 2.1 Principles.- 2.2 Pros and Cons.- 2.3 Comparison with Other Lymphoma Classifications, Including the Working Formulation.- 2.4 Cytological Basis.- 2.4.1 T-Cell Series.- 2.4.2 B-Cell Series.- 2.5 Statistical Data.- 2.5.1 Malignant Lymphomas of Childhood.- 2.6 Therapeutic Principles by M. Engelhard and G. Brittinger.- 2.6.1 Requirements and Principles of Treatment.- 2.6.2 Treatment of Localized Disease.- 2.6.3 Treatment of Advanced Low-Grade Malignant NHL.- 2.6.4 Treatment of Advanced High-Grade Malignant NHL.- 2.6.5 Prospects.- 3 B-Cell Lymphomas.- 3.1 Low-Grade Malignant Lymphomas of B-Cell Type.- 3.1.1 Lymphocytic Lymphomas.- 3.1.1.1 Chronic Lymphocytic Leukaemia of B-Cell Type (B-CLL).- Addendum: Prolymphocytic Leukaemia of B-Cell Type (B-PLL).- 3.1.1.2 Hairy Cell Leukaemia (HCL).- 3.1.2 Lymphoplasmacytic/Lymphoplasmacytoid Lymphoma (Immunocytoma).- Addendum: Heavy Chain Diseases.- 3.1.3 Plasmacytic Lymphoma (Plasmacytoma).- Addendum: Angiofollicular Hyperplasia (Castleman's Disease) with a High Content of Plasma Cells.- 3.1.4 Centroblastic-Centrocytic Lymphoma.- Addendum: Cytological Variants of Centroblastic-Centrocytic Lymphoma.- 3.1.5 Centrocytic Lymphoma (Mantle Cell Lymphoma).- 3.1.6 Monocytoid B-Cell Lymphoma (Including Marginal Zone Cell Lymphoma).- Addendum: Low-Grade Malignant B-Cell Lymphoma of MALT Type.- 3.2 High-Grade Malignant Lymphomas of B-Cell Type.- 3.2.1 Centroblastic Lymphoma.- 3.2.1.1 Primary Centroblastic Lymphoma.- 3.2.1.2 Secondary Centroblastic Lymphoma.- 3.2.2 Immunoblastic Lymphoma of B-Cell Type.- Addendum: Angio-endotheliotropic (Intravascular) Lymphoma.- 3.2.3 Burkitt's Lymphoma (BL).- 3.2.3.1 Burkitt's Lymphoma with Cytoplasmic Immunoglobulin.- Addendum: Malignant Lymphomas in Immunocompromised Patients.- 3.2.4 Large Cell Anaplastic Lymphoma of B-Cell Type (Ki-1 +).- 3.2.5 Lymphoblastic Lymphoma of B-Cell Type.- 3.3 Rare and Ambiguous Types of B-Cell Lymphoma.- 3.3.1 Large Cell, Sclerosing B-Cell Lymphoma of the Mediastinum.- 3.3.2 Microvillous, Large Cell Lymphoma.- 3.3.3 B-Cell Lymphomas with a High Content of T Cells.- 4 T-Cell Lymphomas.- 4.1 Low-Grade Malignant Lymphomas of T-Cell Type.- 4.1.1 Lymphocytic: Chronic Lymphocytic Leukaemia of T-Cell Type (T-CLL).- Addendum: Prolymphocytic Leukaemia of T-Cell Type (T-PLL).- 4.1.2 Small Cell, Cerebriform T-Cell Lymphomas: Mycosis Fungoides and Sézary's Syndrome.- 4.1.3 Lymphoepithelioid Lymphoma ("Lennert's Lymphoma").- 4.1.4 T-Cell Lymphoma of AILD (LgX) Type.- 4.1.5 T-Zone Lymphoma.- 4.1.6 Pleomorphic, Small Cell T-Cell Lymphoma.- 4.2 High-Grade Malignant Lymphomas of T-Cell Type.- 4.2.1 Pleomorphic, Medium-Sized and Large Cell T-Cell Lymphoma 220 Addendum: Adult T-Cell Leukaemia/Lymphoma (ATLL).- 4.2.2 Immunoblastic Lymphoma of T-Cell Type.- 4.2.3 Large Cell Anaplastic Lymphoma of T-Cell Type (Ki-1 +).- 4.2.4 Lymphoblastic Lymphoma of T-Cell Type, Including T-ALL.- Addendum: Unclassified Lymphoblastic Lymphoma.- 4.3 Rare and Ambiguous Types of T-Cell Lymphoma.- 4.3.1 Hairy Cell Leukaemia of T-Cell Type.- 4.3.2 Large Cell Lymphoma of the Multilobated Cell Type (Pinkus).- 4.3.3 Erythrophagocytic T? Lymphoma (Kadin).- 4.3.4 Malignant Lymphoma of "Plasmacytoid T Cells".- 4.3.5 Lymphohistiocytic Lymphoma.- 4.3.6 Peripheral T-Cell Lymphoma Associated with Haemophagocytic Syndrome (Histiocytic Medullary Reticulosis of Scott and Robb-Smith).- 4.3.7 Signet-Ring Cell Lymphoma of T-Cell Type.- 4.3.8 Liebow's Lymphomatoid Granulomatosis, Midline Granuloma and Angiocentric Lymphoma.- Addendum: Methods for the Diagnosis of Lymphoma.- References.