Basic Mechanisms of the Inflammatory Response.- Neutrophils, Interleukin 8, and Related Chemotactic Cytokines.- Leukotrienes and Chemotaxis-5-Lipoxygenase Activation and Control.- The Respiratory Burst Oxidase.- Cellular Activation Mechanisms: The Blood Platelet as a Model.- Platelet-Neutrophil Interactions.- Proteolysis-Induced Pathomeehanisms in Acute Inflammation and Related Therapeutic Approaches.- Complement Activation.- Proteinase-Protein Inhibitor Interaction.- Attenuation of Inflammatory Disease by Reduction of Interleukin-1 Production or Receptor Antagonism.- Interleukin-6, Its Hepatic Receptor and the Acute Phase Response of the Liver.- Transcriptional Control of Liver Acute Phase Genes by Interleukin-6 and Leukemia Inhibitory Factor.- Disturbance of the Hemostasis and Fibrinolysis Balance by Tumor Necrosis Factor.- Cellular Injury by Oxidants.- Endothelium-Derived Relaxing Factor: Nitric Oxide.- Molecular Aspects of the Chemistry and Biology of Endotoxin.- Bacterial Exotoxins and Acute Lung Failure.- Pathophysiological Aspects of Polytrauma, Shock, and Organ Failure.- Leukotrienes, Oxygen Radicals, and Cytokines in Septicemic Mice.- Baboon Model of E. Coli Sepsis: Summary of Staging, Mechanism, and Diagnostic Markers.