This is the second edition of the third volume in the Monographs on Pathology of Laboratory Animals series. Since the first edition, new information has developed at a remarkable pace. Both editions propose standardized nomenclature that is being used internationally, gaining significant acceptance. The result is improved communications of pathologic data to regulatory agencies and in scientific publications worldwide. New information on the nature and variability of preneoplastic lesions in the liver of laboratory rodents is included in this edition. The book expands data on the accompanying changes in enzyme activity in affected liver cells. Spongiosis hepatis in the rat and its relation to spongiotic pericytoma are discussed thoroughly. Information on many other pathologic entities is brought up to date and new ones are added to this second edition, making it an even more useful and expanded reference text.

The Liver.- Neoplasms.- Foci of Altered Hepatocytes, Rat.- Foci of Altered Hepatocytes, Mouse.- Hepatocellular Adenoma, Liver, Rat.- Hepatocellular Carcinoma, Liver, Rat.- Cholangiofibroma and Cholangiocarcinoma, Liver, Rat.- Cholangioma, Liver, Rat.- Hemangiosarcoma, Liver, Rat.- Hemangioma, Liver, Rat.- Hepatoblastoma, Mouse.- Kupffer's Cell Sarcoma, Liver, Rat.- Spongiosis Hepatis and Spongiotic Pericytoma, Rat.- Focal Carcinoma in Hepatocellular Adenoma, Liver, Mouse.- Hyperplasia, Adenoma, Gallbladder, Hamster.- Mesothelioma, Peritoneum, Induced by Mineral Fibers, Rat.- Non-neoplastic Lesions.- Polyploidy, Liver, Rat.- Intranuclear and Intracytoplasmic Inclusions, Liver, Rat.- Extramedullar Hematopoiesis, Liver, Rat.- Nutritional Fatty Liver, Cirrhosis, and Hepatocellular Carcinoma, Rat, Mouse.- Cirrhosis, Mouse.- Peliosis Hepatis, Rodents.- Hyperplasia, Diffuse, Following Partial Hepatectomy, Mouse.- Oval Cells in Rodent Liver, Mouse, Rat.- Herniation of Liver Through Esophageal Hiatus, Rat.- Viral Infections.- K Virus Infection, Mouse.- Mouse Hepatitis Virus Infection, Liver, Mouse.- Rat Parvovirus Infection, Liver.- Mousepox, Liver, Mouse.- Reovirus Type 3 Infection, Liver, Mouse.- Bacterial Infections.- Tyzzer's Disease in the Rat, Mouse, and Hamster.- Corynebacterium kutscheri Infection, Liver, Mouse and Rat.- Idiopathic Focal Hepatic Necrosis in Inbred Mice.- Multifocal Inflammation, Liver, Rat.- The Salivary Glands.- Histology and Ultrastructure, Salivary Glands, Mouse.- Neoplasms.- Myoepithelioma, Salivary Glands, Mouse.- Adenoma, Adenocarcinoma, Salivary Gland, Mouse.- Polyoma Virus Infection, Salivary Glands, Mouse.- Non-neoplastic Lesions.- Cytomegalovirus Infection, Salivary Glands, Mouse, Rat, and Hamster.- Sialodacryoadenitis (SDA) VirusInfection, Rat.- The Exocrine Pancreas.- Embryology, Histology, and Ultrastructure of the Exocrine Pancreas.- Neoplasms.- Acinar Cell Carcinoma, Pancreas, Rat.- Experimental Carcinogenesis, Exocrine Pancreas, Hamster and Rat.- Non-neoplastic Lesions.- Atrophy, Exocrine Pancreas, Rat.- Exocrine Pancreas of Hypophysectomized Rats.- Necrotizing Pancreatitis Induced by 4-Hydroxyaminoquinoline, Rat.- The Oral Cavity.- Squamous Cell Carcinoma, Tongue, Rat.- The Esophagus.- Neoplasms.- Squamous Cell Papilloma, Esophagus, Rat.- Carcinoma In Situ, Esophagus, Rat.- Squamous Cell Carcinoma, Esophagus, Rat.- Papillary and Nonpapillary Squamous Cell Carcinoma, Esophagus, Rat (Zinc Deficiency, Alcohol, and Methylbenzylnitrosamine).- Adenocarcinoma, Esophagus, Rat.- Adenosquamous Carcinoma, Esophagus, Rat.- The Stomach.- Anatomy, Histology, Ultrastructure, Stomach, Rat.- Neoplasms.- Papilloma, Forestomach, Rat.- Squamous Cell Carcinoma Forestomach, Rat.- Adenoma, Glandular Stomach, Rat.- Adenocarcinoma, Glandular Stomach, Rat.- Leiomyoma and Leiomyosarcoma, Stomach, Rat.- The Small Intestines.- Viral Infections.- Mouse Hepatitis Virus Infection, Intestine, Mouse.- Murine Rotavirus Infection, Intestine, Mouse.- Adenovirus Infection, Intestine, Mouse, Rat.- Infectious Diarrhea of Infant Rats (Rotavirus).- Bacterial Infections.- Clostridial Enteropathies, Hamster.- Citrobacter freundii Infection, Colon, Mouse.- Proliferative Ileitis, Hamster.- Streptococcal Enteropathy, Intestine, Rat.- Helminth and Protozoal Infections.- Spironucleus muris Infection, Intestine, Mouse, Rat, and Hamster.- Giardia muris Infection, Intestine, Mouse, Rat, and Hamster.- The Large Intestine.- Bacterial Infection.- Coliform Typhlocolitis, Immunodeficient Mice.- Neoplasms.- Adenocarcinoma, Colon and Rectum, Rat.