The LNCS journal Transactions on Large-Scale Data- and Knowledge-Centered Systems focuses on data management, knowledge discovery, and knowledge processing, which are core and hot topics in computer science. Since the 1990s, the Internet has become the main driving force behind applicational development in all domains. An increase in the demand for resource sharing across different sites connected through networks has led to an evolvement of data- and knowledge-management systems from centralized systems to decentralized systems enabling large-scale distributed applications providing high scalability. Current decentralized systems still focus on data and knowledge as their main resource. Feasibility of these systems relies basically on P2P (peer-to-peer) techniques and the support of agent systems with scaling and decentralized control. Synergy between Grids, P2P systems, and agent technologies is the key to data- and knowledge-centered systems in large-scale environments.

Modeling and Management of Information Supporting Functional Dimension of Collaborative Networks.- A Universal Metamodel and Its Dictionary.- Data Mining Using Graphics Processing Units.- Context-Aware Data and IT Services Collaboration in E-Business.- Facilitating Controlled Tests of Website Design Changes Using Aspect-Oriented Software Development and Software Product Lines.- Frontiers of Structured Business Process Modeling.- Information Systems for Federated Biobanks.- Exploring Trust, Security and Privacy in Digital Business.- Evolution of Query Optimization Methods.- Holonic Rationale and Bio-inspiration on Design of Complex Emergent and Evolvable Systems.- Self-Adaptation for Robustness and Cooperation in Holonic Multi-Agent Systems.- Context Oriented Information Integration.- Data Sharing in DHT Based P2P Systems.- Reverse k Nearest Neighbor and Reverse Farthest Neighbor Search on Spatial Networks.