This book constitutes the thoroughly refereed post-workshop proceedings of the 5th International Workshop on Agents and Peer-to-Peer Computing, AP2PC 2006, held in Hakodate, Japan, in May 2006, in the context of the 5th International Joint Conference on Autonomous Agents and Multi-Agent Systems, AAMAS 2006.

Invited Paper.- Information Flow Analysis in Autonomous Agent and Peer-to-Peer Systems for Self-organizing Electronic Health Records.- P2P Infrastructure.- Hybrid DHT Design for Mobile Environments.- DANTE: A Self-adapting Peer-to-Peer System.- The Exclusion of Malicious Routing Peers in Structured P2P Systems.- Agents in P2P.- Cooperative CBR System for Peer Agent Committee Formation.- Mobile Agent-Based Approach for Resource Discovery in Peer-to-Peer Networks.- P2P Search.- Chora: Expert-Based P2P Web Search.- K-link: A Peer-to-Peer Solution for Organizational Knowledge Management.- An Analysis of Interest-Community Facilitated Peer-to-Peer Search.- Applications.- Mitigating the Impact of Liars by Reflecting Peer's Credibility on P2P File Reputation Systems.- A Comparative Study of Reasoning Techniques for Service Selection.- PROSA: P2P Resource Organisation by Social Acquaintances.- Reliable P2P File Sharing Service.- Studying Viable Free Markets in Peer-to-Peer File Exchange Applications without Altruistic Agents.- Distributed Multi-layered Network Management for NEC Using Multi-Agent Systems.- Facilitating Collaboration in a Distributed Software Development Environment Using P2P Architecture.- A Peer to Peer Grid Computing System Based on Mobile Agents.