This book presents the development and experimental validation of the structural test strategy called Oscillation-Based Test - OBT in short. The results presented here assert, not only from a theoretical point of view, but also based on a wide experimental support, that OBT is an efficient defect-oriented test solution, complementing the existing functional test techniques for mixed-signal circuits.

"This volume attempts to summarize the current state of knowledge on mechanisms underlying the various effects of analgesics, their side effect profiles, and their indications and contraindications in clinical use. It also gives insights into current efforts to discover novel mechanisms underlying the generation of different types of pain and the resulting development of new modulating compounds. TOC:I. Introduction. 1. Peripheral and Central Mechanisms of Pain Generation.- II. Drugs in Clinical Use. 2. Opioids. 3. Antipyretic Analgesics: Cyclooxygenase Inhibitors, Paracetamol and Pyrazolinones. 4. Local Anesthetics. 5. Serotonin Receptor Ligands: Treatments of Acute Migrain and Cluster Headache. 6. Anti-Convulsants and Anti-Depressants.- III. Compounds in Preclinical Development. 7. Neuropeptide and Kinin Antagonists. 8. Glutamate Receptor Ligands. 9. Adrenergic and Cholinergic Compounds. 10. Cannabinoids and Pain.- IV. Future Targets in Analgesia Research. 11. Adenosine and ATP Receptors. 12. Ion Channels in Analgesia Research. 13. Protein Kinases as Potential Target for the Treatment of Pathological Pain.- V. Pain Management Beyond Pharmacotherapy. 14. Placebo and Endogenous Mechanisms of Analgesia. 15. Limitations of Pharmacotherapy - Behavioral Approaches to Chronic Pain."

Peripheral and Central Mechanisms of Pain Generation.- Drugs in Clinical Use.- Opioids.- Antipyretic Analgesics: Nonsteroidal Antiinflammatory Drugs, Selective COX-2 Inhibitors, Paracetamol and Pyrazolinones.- Local Anesthetics.- Serotonin Receptor Ligands: Treatments of Acute Migraine and Cluster Headache.- Anti-convulsants and Anti-depressants.- Compounds in Preclinical Development.- Neuropeptide and Kinin Antagonists.- Glutamate Receptor Ligands.- Adrenergic and Cholinergic Compounds.- Cannabinoids and Pain.- Future Targets in Analgesia Research.- Adenosine and ATP Receptors.- Ion Channels in Analgesia Research.- Protein Kinases as Potential Targets for the Treatment of Pathological Pain.- Pain Management Beyond Pharmacotherapy.- Placebo and Endogenous Mechanisms of Analgesia.- Limitations of Pharmacotherapy: Behavioral Approaches to Chronic Pain.