The new edition of this atlas integrates all significant advances made in the past 15 years in molecular pathology,tumor virology,and genetics of cervical cancer. It emphasizes the importance of these advances in facilitating its pathological diagnosis and in op- mizing clinical management and prognosis. A new chapter on immunohistochemistry has been added,which includes refined detection methods,e. g. ,the overexpression of INK4a p16 as a molecular marker in the early differential diagnosis of premalignant - sions. The section on etiology and pathogenesis in human papillomavirus-induced neoplasia has been incorporated to represent new insights into the sequences of cel- lar and nuclear deregulation at the molecular level. All chapters have been revised to - clude the newest advances and relevant experiences in how to interpret and manage cervical disease; they are supported by the addition of 35 new microphotographic ill- trations. The tumor nomenclature is adapted to the latest edition of the WHO classi- cation; the morphology code of the international classification of diseases for oncology (ICD-O) has been added. We have also updated the list of references by adding recent relevant publications. Again,the staff of Springer-Verlag deserve our thanks for their patience and skill in preparing the manuscript and in reproducing the microphotographs. Heidelberg,February 2005 Gisela Dallenbach-Hellweg, Magnus von Knebel Doeberitz, and Marcus J. Trunk Heading2 Preface to the First Edition During the past decade our understanding of the histopathology of the cervix uteri has changed greatly.

"The second edition of this atlas provides a detailed histopathological diagnosis of cervical disease emphasizing carcinogenesis, and correlating morphologic changes with clinical aspects. Instructions of how to obtain and handle tissue samples are followed by a description of the normal histology, of the action of steroid hormones on the cervix, and of the various forms of regeneration and inflammation. The section on etiology and pathogenesis of HPV-induced neoplasia has been enlarged to explain new insights into cellular and nuclear deregulation at the molecular level. A chapter on immunohistochemistry has been added which includes refined detection methods, e.g., with p16 for the early differential diagnosis of premalignant lesions. The latest advances in molecular biological research, with predictive subdivision of neoplasias, facilitate the choice of the proper therapy. All chapters - supported by over 20 new microphotographs - have been revised to include advances in the interpretation and management of cervical disease. The tumor nomenclature is adapted to the new WHO classification; the ICD-O code has been added. The reference list is updated with relevant publications. TOC:Screening for Cervical Cancer Precursors to Prevent Invasive Disease.- Methods of Obtaining and Preparing Cervical Tissue for Histological Examination.- Immunohistochemistry and In-Situ Hybridization.- Normal Histology, Regeneration, and Repair.- Vestigial and Heterotopic Tissues.- Hormonally Induced Changes.- Inflammatory Lesions.- Benign Tumors.- Premalignant Lesions.- Malignant Tumors."

Screening for Cervical Cancer Precursors to Prevent Invasive Disease.- Methods of Obtaining and Preparing Cervical Tissue for Histological Examination.- Immunohistochemistry and In Situ Hybridization.- Normal Histology, Regeneration, and Repair.- Vestigial and Heterotopic Tissues.- Hormonally Induced Changes.- Inflammatory Lesions.- Benign Tumors.- Premalignant Lesions.- Malignant Tumors.