The third edition of this popular work is revised to include the latest developments in this fast-changing field. Its interdisciplinary approach elegantly combines the chemistry and engineering to explore the fundamentals and optimization processes involved.

INTRODUCTIONFUNDAMENTALS AND GENERAL TERMINOLOGYPrinciples of Adsorption ChromatographyBasic Effects and Chromatographic DefinitionsEquilibrium ThermodynamicsFluid DynamicsMass Transfer PhenomenaReferencesSTATIONARY PHASES AND CHROMATOGRAPHIC SYSTEMSColumn PackingsSelection of Chromatographic SystemsReferencesCHROMATOGRAPHY EQUIPMENT: ENGINEERING AND OPERATIONIntroductionChallenges for Conceptual Process DesignEngineering and Operational ChallengesCommercial Chromatography ColumnCommercial Chromatography SystemsStandard Process ControlPacking MethodsProcess TroubleshootingDisposable Technology for Bio-separationsReferencesPROCESS CONCEPTSDiscontinuous ProcessesContinuous ProcessesChoice of Process conceptsReferencesMODELING AND MODEL PARAMETERSIntroductionModels for Single Chromatographic ColumnsModeling HPLC PlantsCalculation MethodsParameter DeterminationReferencesMODEL BASED DESIGN, OPTIMIZATION AND CONTROLBasic Principles and DefinitionsIsocratic Batch ChromatographyGradient Batch ChromatographyRecycling ChromatographyConventional Isocratic SMB ChromatographyIsocratic SMB Chromatography under Variable Operating ConditionsGradient SMB ChromatographyPractical Approaches for Design of SMB ChromatographyProcess Configuration and Optimization by SuperstructuresAdvanced Process ControlReferences