Unparalleled in its scope and depth, this book brings together proteomic approaches in diagnosis and treatment from all clinical fields, including clinical toxicology. The result is a new discipline in molecular medicine that will revolutionize the treatment and prevention of cancer, stroke and other severe diseases.Following an overview of clinical proteomics, the authors look at the technologies available, before moving on to cancer, cardiopulmonary disease, diabetes and stroke. A whole section is devoted to toxicity and the work is rounded off with a discussion of the future of clinical proteomics.

Editors OverviewPART 1: TECHNOLOGIESPre-analytical issues in clinical proteomic studiesProtein separation by 2DEProtein separation : liquid chromatographyHPLC in protein discoveryIEF analysis of peptides for biomarkers analysisCapillary electrophoresis separations for clinical proteomics Quantitative proteomics using nanoLC with high accuracy mass spectrometryAntibody microarrays for protein and glycan detectionBiomarker Identification: The Role of Experimental Design, Statistics, and Data SharingPART 2: CANCERApplications of stable isotope tagging based quantitive proteomics in cancer research2-D liquid seperations, protein microarrays and mass spectrometry in comprehensive analysis of PTM and biomarker discoveryDevelopment and Use of Reversed-Phase Protein Microarrays for Clinical ApplicationsCDK1 and cancer: usefulness of proteomic approaches in assesment of the molecular mechanisms and efficacy of novel therapeuticsPART 3: CARDIOVASCULAR DISEASEDiagnostic markers for monitoring heart transplant rejectionThe study of microheterogeneity in human plasma proteins: applications to acute myocardial infarctionDiscovery of biomarkers for cardiovascular diseasesDevelopment of biomarker Developfment Pipeline: Search for Myocardial Ischemia BiomarkersAlbuminome as a tool for biomarker discoveryPART 4: VASCULAR DISEASESApplication of Metabolomics to Cardiovascular Biomarker and Pathway DiscoveryUrinary biomarkers in diabetic nephropathy and other glomerular diseases Pulmonary proteomicsProteomics providing insights into major psychiatric disordersPART 6: BIOMARKERSRedox Proteomics Analysis of Oxidative Modified Brain Proteins in Alzheimer¿s Disease and Mild Cognitive Impairment: Insights into the Progression of This Dementing DisorderToxicoproteomics: correlating tissue and serum proteins in liver injuriesBiomarkers for renal disease and uraemic toxinsHIV and other viral screens PART 6: AUTOANTIBODIES AND SIGNATURE BIOMARKERSApplication of Fungal Cyclic Peptides and MetabolitesMicroarray approaches to autoantibody profilingIdentification of tumor antigen-directed autoantibodiesPART 7: FUTUREAntibody and Reverse Capture Protein MicroarraysUse of Antibody Microarrays in the Analysis of Inflammation, Autoimmunity, Viral Infection, and Cancer MetastasesThe Future: Translation from Discovery to the Clinic - Roles of HUPO and industry in biomarker discovery