Mit diesem Band verschaffen Sie sich einen Überblick über den gegenwärtigen Stand der Forschung auf dem Gebiet der Impfstoffe. Ausgehend von neuen Erkenntnissen in Molekularbiologie und Immunologie erläutern rund 30 Artikel Ansätze, die sich momentan im Übergang von der Grundlagenforschung zur Anwendung in der Humanmedizin befinden, sowie zukünftige Strategien. Auch hochaktuelle Themen, unter anderem die Abwehr biologischer Kampfstoffe, werden diskutiert.

PART IPrefaceIntroduction: Challenges for the vaccine developer, including correlates of protectionPART IIVACCINATION AND IMMUNE RESPONSEShaping adaptive immunity against pathogens: the contribution of innate immune responsesAdjuvant induced Th2 and Th1 dominated immune responses in vaccinationMemoryT-cell based vaccinesPART IIIADJUVANTSMicrobial adjuvantsHost derived adjuvantsMicroparticles as vaccine adjuvants and delivery systems Liposomes and ISCOMsVirosomal technology and mucosal adjuvantsPART IVCLASSICAL AND NOVEL VACCINATION STRATEGIES: A COMPARISONClassical bacterial vaccinesSubunit vaccines and toxoidsEngineering virus vectors for subunit vaccinesUpdate on antiviral DNA vaccine research (2000-2003)Live recombinant bacterial vaccinesMucosal vaccinationPassive vaccination and antidotes: A novel strategy for generation of wide-spectrum protective antibodiesPlant-based oral vaccinesVirus-like particles: Combining innate and adaptive immunity for effective vaccinationPART VVACCINES FOR SPECIFIC TARGETSHelicobacter pyloriTuberculosis: Novel vaccination strategies against tuberculosisRationale for malaria vaccine developmentHIVVaccines against bioterror agentsPart VIVACCINES IN THE REAL WORLD: SAFETY, COST-EFFICIENCY AND IMPACT OF VACCINATION Imperfect vaccines and the evolution of pathogen virulenceCost-effectiveness of vaccinationsImmunological safety of vaccines: facts, hypothesis and allegationsIndex