Provides a comprehensive treatment of the underlying concepts and the practical applications in metabolic engineering.

Part I - Concepts1 Metabolic Engineering Perspectives2 Genome-Scale Models: Two Decades of Progress and a 2020 Vision3 Quantitative Metabolic Flux Analysis Based on Isotope Labeling4 Proteome Constraints in Genome-Scale Models5 Kinetic Models of Metabolism6 Metabolic Control Analysis7 Thermodynamics of Metabolic Pathways8 Pathway Design9 Metabolomics10 Genome Editing of EukaryaPart II - Applications11 Metabolic Engineering of Escherichia coli12 Metabolic Engineering of Corynebacterium glutamicum13 Metabolic Engineering of Bacillus - New Tools, Strains, and Concepts14 Metabolic Engineering of Pseudomonas15 Metabolic Engineering of Lactic Acid Bacteria16 Metabolic Engineering and the Synthetic Biology Toolbox for Clostridium17 Metabolic Engineering of Filamentous Actinomycetes18 Metabolic Engineering of Yeast19 Harness Yarrowia lipolytica to Make Small Molecule Products20 Metabolic Engineering of Filamentous Fungi21 Metabolic Engineering of Photosynthetic Cells ? in Collaboration with Nature22 Metabolic Engineering for Large-Scale Environmental Bioremediation