Mushroom have a good nutritive value so these are used as food by human being. Some species of mushroom provide vitamins such as thiamine, riboflavin, niacin, biotin, cobalamine, ascorbic acid and some minerals selenium, Potassium, Phosphorus. Mushrooms have very less calories and contain approximately 80 to 90 percent water. At the same time, they have low sodium, carbohydrate and fat content and high fiber content. This is the reason why mushrooms are considered good for those aiming for weight loss. Since potassium helps lower blood pressure and diminished the risk of stroke, mushrooms are recommended to people suffering from hypertension. Mushrooms are rich in copper, a mineral that has cardio-protective properties. A single serving of mushrooms is said to provide about 20 to 40 percent of the daily needs of copper. Mushrooms are believed to help fight against cancer. They are an excellent source of selenium, an antioxidant that works with vitamin E to protect cells from the damaging effects of free radicals. Some pathogens which decreases the production and quality of mushroom. Therefore in this book bio-control agent strategy was used to control disease.