Novel Lipid based carrier system for Delivery of Pitavastatin Calcium

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The aim of this work is to prepare self-micro-emulsifying drug delivery system (SMEDDS) for oral bioavailability enhancement of a poorly water soluble drug, Pitavastatin. Solubility of Pitavastatin was determined in various vehicles. SMEDDS is mixture of surfactants, oils and co-surfactants, which are emulsi¿ed in aqueous media under conditions of digestive motility and gentle agitation that would be take place in the gastro-intestinal (GI) tract. Pseudo-ternary phase diagrams were made to detect the ef¿cient self-emulsi¿cation region and particle size distributions of the resulting micro-emulsions were resolute using a laser diffraction sizer. Optimized formulations for in vitro dissolution and bioavailability assessment were Capmul PG 8, Tween 80 and Transcutol P. The release rate of Pitavastatin from SMEDDS have signi¿cantly higher than the conventional tablet. These suggest the superiority of prepared SMEDDS of Pitavastatin calcium for In-vitro drug release that may further in enhancement of bioavailability. Our studies illustrated the prospective use of SMEDDS for the delivery of hydrophobic compounds, such as Pitavastatin by the oral route.
Autor: Suresh Kumar Joshi, Bharti Mangla, Praveen Parashar
Suresh Kumar Joshi is a renowned researcher and a research scientist. He obtained his B.Pharm in 2010-14 and after qualifying GPAT-2014, completed M.Pharm(Pharmaceutics) in the year 2016. He has published more than 8 research papers in International & National journals with good impact points and several poster and paper presentation for his credit

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Autor: Suresh Kumar Joshi
ISBN-13 :: 9783330040335
ISBN: 3330040335
Verlag: LAP Lambert Academic Publishing
Gewicht: 130g
Seiten: 76
Sprache: Englisch
Sonstiges: Taschenbuch, 220x150x5 mm
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