This book introduces and discusses the most important aspects of clinical research methods and biostatistics for oncologists, pursuing a tailor-made and practical approach.

A tailor-made book on clinical research and biostatistics in oncology.

Preface.- Introduction.- 1. Background of scientific method in oncology.- 2. Writing a hypothesis for a oncology study.- 3. Type of variables and distributions.- 4. Testing measures of association.- 5. Sample size calculation for oncology trials.- 6. Uni and multivariate analysis (understanding of regressions) in cancer research.- 7. Survival analyses in cancer trials.- 8. The role of transversal and cohort studies in oncology.- 9. Design of retrospective and case-control studies in oncology.- 10. Minimizing differences by randomization.- 11. How to design phase I trials in oncology.- 12. The many different designs of phase II oncology trials.- 13. Superiority and non-inferiority phase III oncology trials.- 14. Phase IV oncology trials.- 15. Analysis of graphs in clinical cancer research.- 16. Identifying biases in clinical cancer research.- 17. Ethics in clinical cancer research.- 18. Cost-effectiveness studies in oncology.- 19. How to undertake outcomes research in oncology.- 20. Systematic review and meta-analysis of oncology studies.- 21. Meta-research in oncology.- 22. Analysis of quality of life and patient-reported outcomes in oncology.- Exercises.- Commented answers.- Glossary.- Remissive index.