Beschreibung:
This book presents the latest advances concerning the regulation of chromosome segregation during cell division by means of centromeres and kinetochores. The authors cover both state-of-the-art techniques and a range of species and model systems, shedding new light on the molecular mechanisms controlling the transmission of genetic material between cell divisions and from parent to offspring.
Female Germ Cells.- Cell Biology of Cheating-Transmission of Centromeres and Other Selfish Elements Through Asymmetric Meiosis.- Biophysics of Microtubule End Coupling at the Kinetochore.- Molecular Mechanisms of Spindle Assembly Checkpoint Activation and Silencing.- A Kinase-Phosphatase Network That Regulates Kinetochore-Microtubule Attachments and the SAC.- Centromeric Cohesion: Molecular Glue and Much More.- Centromere Structure and Function.- The Role of Centromere Defects in Cancer.