This book examines in depth the evidence, clinical applications and potential cancer signatures in the circulation and discusses alterations in circulating cell-free nucleic acids, and circulating tumor DNA, as well as the epigenome, genome, transcriptome (coding and noncoding), proteome (both traditional serum proteins and proteomic profiles) and metabolome. Further, it highlights the clinical applications of circulating tumor cells for each cancer type and addresses the emerging importance of extracellular vesicular contents, including miRNA, oncogenes and drug resistant factors. As such, it offers a valuable reference guide for cancer researchers, oncologists, clinicians, surgeons, medical students, oncology nurses, diagnostic laboratories, and the pharmaceutical industry.

Presents cancer biomarkers for noninvasive diagnosis of 18 different body fluids

1. Melanoma Biomarkers in Circulation. - 2. Head and Neck Cancer Biomarkers in Circulation. - 3. Lung Cancer Biomarkers in Circulation. - 4. Breast Cancer Biomarkers in Circulation. - 5. Esophageal Cancer Biomarkers in Circulation. - 6. Gastric Cancer Biomarkers in Circulation. - 7. Colorectal Cancer Biomarkers in Circulation. - 8. Hepatocellular Carcinoma Biomarkers in Circulation. - 9. Pancreatic Cancer Biomarkers in Circulation. - 10. Renal Cell Carcinoma Biomarkers in Circulation. - 11. Urothelial Bladder Cancer Biomarkers in Circulation. - 12. Prostate Cancer Biomarkers in Circulation. - 13. Ovarian Cancer Biomarkers in Circulation. - 14. Endometriosis Biomarkers in Body Fluids. - 15. Endometrial Cancer Biomarkers in Circulation. - 16. Cervical Cancer Biomarkers in Circulation. - 17. Endocrine Cancer Biomarkers in Circulation. - 18. Brain Tumor Biomarkers in Circulation.