This volume of the established Subcellular Biochemistry series presents 20 chapters dealing with a broad range of interesting protein complexes. It will enable researchers to readily appreciate the major contribution from both X-ray crystallography and cryo-electron microscopy in this field of study.

1 Structure and function of the stressosome signalling hub, Jan Pané-Farré, Maureen B. Quin, Richard J. Lewis, Jon Marles-Wright.- 2 The Canonical Inflammasome - a macromolecular complex driving inflammation, Tom P. Monie.- 3 The Ferritin superfamily, Alejandro Yévenes.- 4 Antibody Recognition of Immunodominant Vaccinia Virus Envelope Proteins, Dirk M. Zajonc.- 5 The Peroxiredoxin Family: An Unfolding Story, Zhenbo Cao and J. Gordon Lindsay.- 6 a2-Macroglobulins: structure and function, Irene Garcia-Ferrer, Aniebrys Marrero, F. Xavier Gomis-Rüth, Theodoros Goulas.- 7 The Structure and Function of the PRMT5:MEP50 Complex, Stephen Antonysamy.- 8 Symmetry-Directed Design of Protein Cages and Protein Lattices and their Applications, Aaron Sciore and E. Neil G. Marsh.- 9 STRUCTURE AND Funtion RNA Polymerases and the Transcription Machineries, Joachim Griesenbeck, Herbert Tschochner and Dina Grohmann.- 10 Dihydrodipicolinate synthase: Structure, dynamics, function, and evolution, F. Grant Pearce, André O. Hudson, Kerry Loomes, Renwick C.J. Dobson.- 11 Pyruvate Carboxylase, Structure and Function, Mikel Valle.- 12 Cullin-RING E3 Ubiquitin Ligases: Bridges to Destruction, Henry C. Nguyen, Wei Wang, and Yong Xiong.- 13 The Ccr4-Not complex: Architecture and structural insights, Martine A. Collart and Olesya O. Panasenko.- 14 Higher-order structure in bacterial VapBC toxin-antitoxin complexes, Kirstine L. Bendtsen and Ditlev E. Brodersen.- 15 D-glyceraldehyde-3-Phosphate Dehydrogenase Structure and Function, Michael R. White and Elsa D. Garcin.- 16 Protein Complexes in the Nucleus: the control of chromosome segregation, Victor M. Bolanos-Garcia.- 17 GroEL and the GroEL-GroES Complex, Noriyuki Ishii.- 18 The Aminoacyl-tRNA Synthetase Complex, Marc Mirande.- 19 Apoptosome: the caspase-activating machine, Mengying Zhou, Qi Hu, and Yigong Shi.- 20 The Pyruvate Dehydrogenase Complex and Related Assemblies in Health and Disease, Olwyn Byron and J. Gordon Lindsay.- 21 Type III CRISPR-Cas Systems: a structural perspective, Laura Spagnolo.- 22 Structure and assembly of clathrin cages, Mary Halebian, Kyle Morris, Corinne Smith.- Index.