This book contains the refereed contributions from the 43rd annual meeting of ISOTT. The annual meetings of ISOTT bring together scientists from various fields (medicine, physiology, mathematics, biology, chemistry, physics, engineering, etc.) in a unique international forum. ISOTT conferences are a place where an atmosphere of interaction is created, where many questions are asked after each presentation and lively discussions occur at a high scientific level. This vivid interaction is the main motivation for members to participate and gain new ideas and knowledge in the broad field of oxygen transport to tissue. The proceedings include sessions covered various research topics including Multi-Modal Imaging/Spectroscopy & Instrumentation; Cancer Metabolism; Cellular Hypoxia and Mitochondrial Function; Brain Oxygenation and Function; Other Organ Function and Metabolism; Oxygen Transport in Sports, Diseases and Clinical Care; Acupuncture, Meridians, and Primo Vascular System; EPR, MRS and MRI.

ISOTT from the Beginning: A Tribute to Our Deceased Members (Icons).- A Compelling Case for the Use of Perioperative Zymogen Protein C for Increased Patient Safety.- Clinical Evaluation of MP4CO: A Phase 1b Escalating-dose, Safety and Tolerability Study in Stable Adult Patients with Sickle Cell Disease.- Protective Effect of Dl-3-n-butylphthalide on Recovery from Cardiac Arrest and Resuscitation in Rats.- Hypoxia-Induced Let-7d Has a Role in Pericyte Differentiation.- Magnification of Cholesterol-Induced Membrane Resistance on the Tissue Level: Implications for Hypoxia.- Respiratory Pores on Ostrich Struthio camelus (Aves: Struthionidae) Eggshells.- Evaluation of both Free Radical Scavenging Capacity and Antioxidative Damage Effect of Polydatin.- Spectroscopic Studies on the Interaction of Pyridinoline Cross-linking in Type 1 Collagen with ZIF8-HB.- The Role of Free Radicals in the Photodynamic Treatment of Fibrotic Skin Diseases.- Tumor Hypoxia: Causative Mechanisms, Microregional Heterogeneities, and the Role of Tissue-based Hypoxia Markers.- Molecular Imaging of Tumor Hypoxia: Existing Problems and Their Potential Model-based Solutions.- Direct and Repeated Clinical Measurements of pO2 for Enhancing Cancer Therapy and Other Applications.- Impact of the Tumor Microenvironment on the Expression of Inflammatory Mediators in Cancer Cells.- Comparing the Effectiveness of Methods to Measure Oxygen in Tissues for Prognosis and Treatment of Cancer.- Potential Indexing of the Invasiveness of Breast Cancer Cells by their Mitochondrial Redox Ratios.- Directional Migration of MDA-MB-231 Cells under Oxygen Concentration Gradients.- Stress-induced Stroke and Stomach Cancer: Sex Differences in Oxygen Saturation.- Changes in Oxygenation Levels Precede Changes in Amplitude of the EEG in Premature Infants.- Effects of Positive and Negative Mood Induction on the Prefrontal Cortex Activity measured by Near Infrared Spectroscopy.- Correlation between the Cerebral OxyhaemoglobinSignal and Physiological Signals during Cycling Exercise: A Near-Infrared Spectroscopy Study.- Effect of Locomotor Respiratory Coupling Induced by Cortical Oxygenated Hemoglobin Levels during Cycle Ergometer Exercise of Light Intensity.- Hypoxia and Neonatal Haemorrhagic Stroke: Experimental Study of Mechanisms.- Interrelationship between Broadband NIRS Measurements of Cerebral Cytochrome C Oxidase and Systemic Changes Indicates Injury Severity in Neonatal Encephalopathy.- PFC Activity Pattern during Verbal WM Task in Healthy Male and Female Subjects: A NIRS Study.- Spatial Distribution of Changes in Oxidised Cytochrome C Oxidase during Visual Stimulation using Broadband Near Infrared Spectroscopy Imaging.- Effects of Physical Exercise on Working Memory and Prefrontal Cortex Function in Post-Stroke Patients.- Relation between Prefrontal Cortex Activity and Respiratory Rate during Mental Stress Tasks: A Near-Infrared Spectroscopic Study.- Effects of Antioxidant Supplements (BioPQQTM) onCerebral Blood Flow and Oxygen Metabolism in the Prefrontal Cortex.- Temporal Comparison between NIRS and EEG Signals during a Mental Arithmetic Task Evaluated with Self-Organizing Maps.- The Role of Phonological Processing in Semantic Access of Chinese Characters: A Near-Infrared Spectroscopy Study.- Improvement of Impaired Cerebral Microcirculation using Rheological Modulation by Drag-Reducing Polymers.- Relationship between Cerebral Oxygenation and Metabolism during Rewarming in Newborn Infants after Therapeutic Hypothermia following Hypoxic-ischemic Brain Injury