This comprehensive overview of endogenous lung stem and progenitor cell organization and regulation in fetal lung development, postnatal lung growth and adulthood deftly compiles and explores the current body of research. Progressing stage by stage, the chapters on fetal lung development emphasize the integrated role of epithelial, stromal, vascular and neural cell elements in building a functional lung, while the subsequent chapters on adult lung regeneration describe the nature and properties of adult lung stem/progenitor cells distributed along the proximal-distal axis of the airway tree. The chapters on regulation of lung regeneration and repair discuss how regenerative cells interact with their niche microenvironment and how regulation of lung regeneration and repair in the steady state and following injury recapitulates ontogeny. And, lastly, the chapters on cellular therapies for lung disease and bioengineering the lung focus on promising emerging therapies and approaches in lung regenerative medicine.

Part 1. Fetal Lung Development.- The Regulation of Branching Morphogenesis in the Developing Lung.- Epithelial-Mesenchymal Crosstalk in Lung Development.- Lung Vasculogenesis and Angiogenesis.- Neural Regulation of Lung Development.- Fetal and Neonatal Origins of Lung Disease.- Part 2. Adult Lung Stem and Progenitor Cells.- Stem and Progenitor Cells of the Trachea and Proximal Airways.- Stem and Progenitor Cells of the Distal Bronchiolar Airways.- Regenerative Cells in the Ageing Lung.- Part 3. Regulation of Lung Regeneration and Repair.- Stromal Regulation of Lung Regeneration and Repair.- Immunomodulatory Regulation Of Lung Regeneration and Repair.- Extracellular Matrix Specification of Regenerative Cells in the Adult Lung.- Role of Mechanical Stress in Lung Repair and Regeneration.- Part 4. Cellular Therapies for Lung Disease.- Cellular Origins of Fibrotic Lung Diseases.- Mesenchymal Stromal Cell Based Therapies for Lung Disease.- Lung Vascular Regeneration and Repair.- Directed Differentiation of Human Pluripotent Stem Cells into Lung and Airway Epithelial Cells.- Part 5. Bioengineering the Lung.- Regenerating the Respiratory Tract.- Acellular Lung Scaffolds in Lung Bioengineering.- Part 6. Afterword.-Prospects and Challenges in Lung Regenerative Medicine.