Nuclear Receptors focuses on the structural analysis of nuclear receptors from the initial work using isolated protein domains to the more recent exciting developments investigating the conformational shape of full-length receptor complexes. The book also reviews the structure of key nuclear receptor co-regulatory proteins. The aim is to bring together, for the first time, a comprehensive review of nuclear receptor structure and the importance of receptor conformation underpinning allosteric regulation by different ligands (hormone, drugs, DNA response elements, protein-protein interactions) and receptor activity.

1. Twenty-five Years of Nuclear Receptor Structure Analysis: From the Laboratory to the Clinic.- Part A. ALLOSTERIC REGULATION AND NUCLEAR RECEPTOR COMPLEX DYNAMICS. -2. Corticosteroid Receptors.- 3. Glucocorticoid Receptor Structure and Function.- 4. What Determines the Difference in DNA Binding Between the Androgen and the Glucocorticoid Receptors?.- 5. Allosteric Regulation and Intrinsic Disorder in Nuclear Hormone Receptors.- 6. Structural Analyses of Ordered and Disordered Regions in Ecdysteroid Receptor.- 7. Structural Analysis of Heterodimeric Nuclear Receptors.- Part B. NUCLEAR RECEPTOR CO-REGULATORY PROTEIN INTERACTIONS.- 8. Primate-specific Multi-functional Androgen Receptor Coregulator and Proto-oncogene Melanoma Antigen-A11 (MAGE-A11).- 9. Assembly and Regulation of Nuclear Receptor Corepressor Complexes.- Part C. TAKING NUCLEAR RECEPTOR STRUCTURE INTO THE CLINIC.- 10. Thinking Outside the Box: Alternative Binding Sites in the Ligand Binding Domain of Nuclear Receptors.- 11. Selective Estrogen Receptor Modulators (SERMs) and Selective Androgen Receptor Modulators (SARMs).