Beschreibung:
This volume provides a comprehensive, state-of-the art review on the field of diagnostic hematopathology as it is applied to patients with plasma cell neoplasms. The book places particular emphasis on immunophenotypic data - immunohistochemistry and flow cytometry - as well as cytogenetics, and discusses how these ancillary data can predict prognosis and chemotherapeutic response. It also provides a concise yet comprehensive summary of the current status of the field that will help guide patient management and stimulate investigative efforts.
Introduction.- Protein studies.- Electrophoresis and immunofixation.- Serum free light chain analysis.- Morphology and immunohistochemistry of normal and neoplastic plasma cells.- Classification of plasma cell neoplasms.- Monoclonal gammopathy of undetermined significance.- Plasma cell myeloma.- Plasmacytoma - solitary and extraosseus.- Monoclonal immunoglobulin deposition diseases.- Cytogenetics.- Flow cytometry.- Integration of laboratory and clinical data into synoptic report.- Approaches to treatment, including stem cell transplant.- Conclusions.- References.