This book describes a comprehensive framework for hardware/software co-design, optimization, and use of robust, low-cost, and cyberphysical digital microfluidic systems. Readers with a background in electronic design automation will find this book to be a valuable reference for leveraging conventional VLSI CAD techniques for emerging technologies, e.g., biochips or bioMEMS. Readers from the circuit/system design community will benefit from methods presented to extend design and testing techniques from microelectronics to mixed-technology microsystems. For readers from the microfluidics domain, this book presents a new design and development strategy for cyberphysical microfluidics-based biochips suitable for large-scale bioassay applications.¿ Takes a transformative, ¿cyberphysical¿ approach towards achieving closed-loop and sensor feedback-driven biochip operation under program control;¿ Presents a ¿physically-aware¿ system reconfiguration technique that uses sensor data at intermediate checkpoints to dynamically reconfigure biochips;¿ Enables readers to simplify the structure of biochips, while facilitating the ¿general-purpose¿ use of digital microfluidic biochips for a wider range of applications.

Takes a transformative, "cyber physical" approach towards achieving closed-loop and sensor feedback-driven biochip operation under program control

Introduction.- Error-Recovery in Cyberphysical Biochips.- Real-Time Error Recovery Using a Compact Dictionary.- Biochemistry Synthesis under Completion-Time Uncertainties in Fluidic Operations.- Optimization of On-Chip Polymerase Chain Reaction.- Pin-Count Minimization for Application-Independent Chips.- Pro-Limited Cyberphysical Microfluidic Biochip.- Conclusions.