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Calcium Channel Blockers
ISBN-13:
9783034878593
Veröffentl:
2012
Seiten:
262
Autor:
Théophile Godfraind
Serie:
Milestones in Drug Therapy
eBook Typ:
PDF
eBook Format:
EPUB
Kopierschutz:
1 - PDF Watermark
Sprache:
Englisch
Beschreibung:
The main effect of calcium channel blockers is the blockade of calcium entry into cells through voltage operated calcium channels. This volume gives a comprehensive overview of the different classes of CCBs and their various effects. It covers historical development, pharmacology, clinical aspects, and perspectives. All chapters are written by Prof. T. Godfraind, a world leading expert in the field.
Historical perspective: from early steps on calcium research to the identification of calcium antagonist prototypes and of the signaling functions of Ca2+.- Calcium channel blockers and calcium channels.- The action of calcium antagonists on Ca2+ movements in isolated vessels.- The tissue selectivity of calcium antagonists.- Acute haemodynamic effects of calcium channel blockers.- Calcium channels and regulation of vascular tone in hypertension.- Long-term effects of calcium antagonists.- Blood pressure-independent effects of calcium antagonists.- From early clinical studies to randomized controlled clinical trials.- Beyond the cardiovascular system.
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