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Matrix Metalloproteinase Inhibitors
Specificity of Binding and Structure-Activity Relationships
Sofort lieferbar | Lieferzeit: Sofort lieferbar I
ISBN-13:
9783034803649
Veröffentl:
2012
Seiten:
286
Autor:
Satya Prakash Gupta
Serie:
103, Experientia Supplementum
eBook Typ:
PDF
eBook Format:
EPUB
Kopierschutz:
1 - PDF Watermark
Sprache:
Englisch
Beschreibung:
Matrix metalloproteinases (MMPs) are proteolytic enzymes that are involved in many physiological and pathological processes. The field of MMP research is very important due to the implications of the distinct paralogs in both human physiology and pathology. Over-activation of these enzymes results in tissue degradation, producing a wide array of disease processes such as rheumatoid arthritis, osteoarthritis, tumor growth and metastasis, multiple sclerosis, congestive heart failure, and others. Thus MMP inhibitors are candidates for therapeutic agents to combat a number of diseases.
Matrix Metalloproteinases.- Specificity of Binding with Matrix Metalloproteinases.- The Gelatinases and Their Inhibitors: The Structure-Activity Relationships.- Advances in Studies on Collagenase Inhibitors.- Hydroxamic Acids as Matrix Metalloproteinase Inhibitors.- Quantitative Structure-Activity Relationship Studies on Sulfonamide-Based MMP Inhibitors.- Matrix Metalloproteinase Inhibitors as Investigative Tools in the Pathogenesis and Management of Vascular Disease.
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