Beschreibung:
Obesity is a worldwide epidemic that affects half a billion people. It has been estimated that, if current trends continue, by 2050, 60% of men and 50% of women worldwide will be obese. Hypertrophy and hyperplasia of white adipose tissue caused by overweight and obesity lead to a chronic inflammatory state, which results in impaired insulin sensitivity and the development of diabetes. Currently, the number of people affected by diabetes globally exceeds 400 million (rising more rapidly in low- and middle-income countries). In 2019, diabetes was the ninth leading cause of mortality, with an estimated 1.5 million direct deaths.
Inflammation: Pathogenesis and Biological Markers.- Obesity and Inflammation.- Inflammation and Diabetes Mellitus.- Diabetes, Obesity, and Oxidative stress.- Advanced Glycation End-Products and Diabetes.- Genetic and Epigenetic Basis of Obesity-Induced Inflammation and Diabetes.- Inflammation and Vascular Pathologies.- Environmental and Lifestyle Factors Influencing Inflammation and Type 2 Diabetes Onset.- Inflammation in Pregnant Women with Obesity and Gestational Diabetes.- Potential Pharmaceutical and Non-Pharmaceutical Approaches to Obesity and Diabetes: Focus on Inflammation.