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DNA-Encoded Libraries
ISBN-13:
9783031186295
Veröffentl:
2022
Seiten:
276
Autor:
Andreas Brunschweiger
Serie:
40, Topics in Medicinal Chemistry
eBook Typ:
PDF
eBook Format:
EPUB
Kopierschutz:
1 - PDF Watermark
Sprache:
Englisch
Beschreibung:
This book deals with the recent advances in DNA-Encoded Library (DEL) technology that has emerged as an alternative to high throughput screening(HTS) over the last decade and has been heralded as a "disruptive" technology for drug discovery.
A History of Selection-Based High-Throughput Screening Technologies for Hit Identification.- Barcoding Strategies for the Synthesis of Genetically Encoded ChemicalLibraries.- Advancements in DEL-Compatible Chemical Reactions.- Design Considerations in Constructing and Screening DNA-Encoded Libraries.- Cheminformatics Approaches Aiding the Design and Selection of DNA-Encoded Libraries.- Selection Strategies in DNA-Encoded Libraries.- From DEL Selections to Validated Hits to Clinical Leads.- A Perspective on 30 Years of DNA-Encoded Chemistry.
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