This book reviews new promising drug targets for Neglected Tropical Diseases (NTDs), with a special focus on antiprotozoal drugs against trpyanosomatids Trypanosoma cruzi and Leishmania spp. The book offers a comprehensive overview of the most recent studied targets, and it outlines classical and new treatments and delivery strategies. Expert contributors describe new methods of analysis and bio-prospecting for new compounds, and provide a critical perspective of the translational process used in the research and development of new drug candidates.

Classical and Modern Drug Treatments for Leishmaniasis.- Saponins as Potential Antiprotozoa Agents.- Chagas Disease: Drug Development and Parasite Target.- Targeting carbonic anhydrases from Leishmania spp. and Trypanosoma cruzi as a strategy to obtain new drugs.- New Compounds for the Management of Trypanosoma brucei Infection.- Polyamine and Trypanothione Pathways as Targets for Novel Antileishmanial Drugs.- Nano and Microstructured Delivery Systems for Current Antileishmanial Drugs.- Pharmacological Treatment of Malaria.- ¿-Class Carbonic Anhydrases as Antiplasmodial Drug Targets: Current State of the Art and Hurdles to Develop New Antimalarials.- Management of Entamoeba histolytica Infection: Treatment Strategies and Possible New Drug Targets.- Trichomonas vaginalis Pharmacological Treatment.- Beta-Carbonic Anhydrase from Trichomonas Vaginalis as New Antiprotozoan Drug Target.- Drugs for the treatment of toxoplasmosis.- Challenges and promises for obtaining new antiprotozoal drugs - what's going wrong?