This volume elucidates the pivotal ethical and legal issues arising from the use of brain organoids for research, therapeutic and enhancement purposes.

Chapter 1) Introductory Remarks.- Part I) Scientific Background.- Chapter 2) Development of Brain Organoids on the Basis of Genome-Edited iPSC-Derived Brain Cells.- Chapter 3) Cell-Based Therapy and Genome Editing in Parkinson's Disease: Quo Vadis.- Part II) The Status Debate.- Chapter 4) Human Cerebral Organoids: Evolving Entities and Their Moral Status.- Chapter 5). Legal perspective: What is, or Should Be, the Legal Status of Brain Organoids?.- Part III) The Informed Consent Challenge.- Chapter 6) Ethical Perspective: Ethics Considerations Regarding Donors' and Patients' Consent.- Chapter 7) The Legal Perspective: The Legal Requirements for-and Limits to-the Donor's and the Patient's Consent.- Part IV) The Chimera Issue.- Chapter 8) Moral Permissibility of Transplantation of Human Brain Organoids into Animals.- Chapter 9) Transplantation of Human Brain Organoids into Animals - The Legal Issues.- Part V) The Enhancement Conundrum.- Chapter 10) Building a Better Beast: Enhancing the Minds of Animals.- Chapter 11) Legal Arguments in Favour of and Against Neuroenhancement by Means of Brain Organoids.- Part VI) The Harmonization Problem.- Chapter 12) Legal Perspective: A Global Harmonisation of Legal Standards for Brain Organoid Research and Therapy?.