This unique work presents one of the most significant organ failure condition - cardiocirculatory shock - and the prominent role of Methylene Blue (MB). Through their extensive experience, the authors' consider that the lifesaving feature of MB is still underestimated. For this reason they outline key concepts of MB, mentioning essential experimental data, yet focusing mainly on its application in the care of critically ill patients.

Part I - General Conceptual Aspects.- Introduction.- Physiology of the Endothelium.- PART 2- PARTICULARITIES OF ENDOTHELIAL DYSFUNCTION IN DIFFERENT TYPES OF SHOCK.- Circulatory Shock: A Conceptual and Practical Approach.- Circulatory Shock, Ischemia Reperfusion Injury, Inflammatory Response Syndrome (SIRS) and Multiple Organ Failure.- Endothelial Dysfunction in Hemorrhagic Shock.- Endothelial Dysfunction in Cardiogenic Shock.- Endothelial Dysfunction in Distributive Shock.- PART 3- METHYLENE BLUE.- Methylene blue.- The Inhibition of Guanylate Cyclase by Methylene Blue as Therapeutic Proposal for Vasoplegia Associated with Shock.- Methylene Blue in the Treatment of Anaphylaxis.- Methylene Blue in Children and Neonates.- Methylene Blue and Burns.- Cardiac arrest and neuroprotection by methylene blue.- Methylene Blue and Endocarditis.- PART 4 - ENDOTHELIAL DYSFUNCTION IN SPECIFIC SITUATIONS.- Vasoplegic syndrome in heart surgery.- Vasoplegic Endothelial Dysfunction In Orthotopic Liver Transplantation.- Acid-base Balance.- The therapeutic use of inhaled nitric oxide.