Beschreibung:
Split in three parts, the book starts with the basics, followed by more advanced and current research. The first part provides an introduction to essential concepts in population genetics, which are relevant for any organism. The second partcovers the genetics of complex traits in humans. The third part focuses on applying these techniques and concepts to genetic variation data to learn about demographic history and natural selection in humans.
- Part I Population Genetic Theory. - Coalescent Models. - Linkage Disequilibrium. - Analysis of Population Structure. - Types of Natural Selection and Tests of Selection. - Part II Association Studies and Medical Genetics. - Methods for Association Studies. - Identity by Descent in the Mapping of Genetic Traits. - What Have We Learned from GWAS?. - Part III Human Evolutionary Population Genetics. - Inferring Human Demographic History from Genetic Data. - Natural Selection, Genetic Variation, and Human Diversity.