This volume aims to enhance the current understanding of clinical features, treatment and pathogenic aspects in necrotizing soft tissue infections. Various representative case studies are discussed to enhance the readers' understanding of these complex diseases.

Chapter 1: The INFECT-project: An international multidisciplinary project on necrotizing soft tissue infections.- Chapter 2: Necrotizing Soft Tissue Infections: case reports from the patients prospective.- Chapter 3: Necrotizing soft tissue infections: Case-reports, from the clinician's perspectives.- Chapter 4: Necrotizing soft tissue infections: clinical features and diagnostic aspects.- Chapter 5: Microbiological etiology of necrotizing soft tissue infections.- Chapter 6: Beta-hemolytic streptococci and necrotizing soft tissue infections.- Chapter 7: Treatment of necrotizing soft tissue infections: Antibiotics.- Chapter 8: Treatment of necrotizing soft tissue infections: IVIG.- Chapter 9: Pathogenic mechanisms of streptococcal necrotizing soft tissue infections.- Chapter 10: Systems genetics approaches in mouse models of Group A Streptococcal necrotizing soft tissue infections.- Chapter 11: Systems biology and biomarkers in necrotizing soft tissue infections.- Chapter 12: Systems and precision medicine in necrotizing soft tissue infections.