The third edition of this acclaimed work provides clinicians and investigators with a wealth of state-of-the-art information that will lead to fresh approaches in thinking about liver physiology and liver diseases. Developed by a panel of renowned international authors, this edition outlines a range of important advances in our understanding of the liver's role as an immune organ and the functions of innate and adaptive immunity in the pathogenesis of all liver diseases. Indeed, the liver is a vitally important immune organ producing liver-derived products that can trigger the innate and adaptive immune system to initiate, mediate, regulate, and resolve systemic inflammation.

1. Core Concepts in Immunology: The Definition of Autoimmunity and Its Unique Application to the Seat of Tolerance, the Liver.- 2. The Liver as a Lymphoid Organ.- 3. The Uniqueness of Innate Immunity.- 4. Adaptive Immunity and the Clinical Definition of Autoantibodies.-5. Genetics of Autoimmune Liver Diseases.- 6. The Epigenetic Basis of Loss of Tolerance.- 7. Bile Acids and Bilirubin in Liver Immunology.- 8. The Microbiota-Gut-Liver Axis - Implications for the Pathophysiology of Liver Disease.- 9. Diagnostic Liver Immunology.- 10. The Pathologist's Approach to Reviewing Liver Histology.- 11. Geoepidemiology of Autoimmune Liver Diseases.- 12. Immune Responses to Bacterial Infections.- 13. Immunity of Parasitic Infections of the Liver.- 14. The Treatment of Bacterial and Parasitic Diseases of the Liver.- 15. Hepatitis A and Other Viral Infections.- 16. Hepatitis B Virus.- 17. Hepatitis C.- 18. Hepatitis D.- 19. Hepatitis E.- 20. Alcohol-Associated Liver Disease.- 21. Non-alcoholic Fatty Liver Disease: A Chapter in Liver Immunology.- 22. Primary Biliary Cholangitis.- 23. PSC - AIH Overlap.- 24. Primary Biliary Cholangitis: Autoimmune Hepatitis Overlap Syndrome.- 25. Primary Sclerosing Cholangitis .- 26. Autoimmune Hepatitis.- 27. IgG4-related Disease: Current Concept, Diagnosis, and Pathogenesis.- 28. Pediatric Liver Disease.- 29. Mechanisms of Acute Liver Failure.- 30. Immune-Mediated Drug-Induced Liver Injury.- 31. Hepatobiliary Cancers and Immunology.- 32. Acute-on-Chronic Liver Failure.- 33. The Pathogenesis of Liver Diseases in Pregnancy.- 34. Graft-Versus-Host Disease.- 35. Immunopathogenesis of Liver Cirrhosis.- 36. Immune-Mediated Liver Disease in the Transplanted Liver.