This book offers comprehensive information on the new and rapidly evolving science of identifying and targeting senescent cells, and on the exciting prospect of new diagnostic and therapeutic opportunities for stopping, and even reversing, the progression of disease and the deterioration of the human body due to ageing.

Part I: Origins and Development of Senotherapies.- Chapter 1. Senolytic drug development.- Chapter 2. Discovery of Senolytics and the pathway to early phase clinical trials.- Part II: The Impact of Senotherapies: from Regeneration to Aging.- Chapter 3. Interconnection between cellular senescence, regeneration and ageing in salamanders.- Chapter 4. Senolytics target senescent cells and improve aging and age-related diseases.- Chapter 5. Senotherapy of cancer.- Part III: Understanding and Targeting the Senescent Surfaceome.- Chapter 6. Targeted senolytic strategies based on the senescent surfaceome.- Chapter 7. Senolysis and senostasis through the plasma membrane.- Part IV: Novel Senescence-Associated Markers and Targets.- Chapter 8. In situ detection of miRNAs in senescent cells in archival material.- Chapter 9. Novel probes and carriers to target senescent cells.- Chapter 10. Potential applications of aptamers for targeting senescent cells.- Chapter 11. Mitochondria: potential targets for interventions to counteract senescence.