Beschreibung:
This book offers an authoritative review of biopharmaceuticals and their clinical relevance. Biopharmaceuticals have been showing high therapeutic potential by means of biological and biosimilar medicines, particularly for the treatment of cancer, chronic diseases (e.g. diabetes, Crohn's disease, psoriasis and rheumatoid arthritis), neurodegenerative disorders (e.g. multiple sclerosis), and they have also been contributing to the progress of innovative therapies such as assisted reproductive medicine. Since the eighties, several biopharmaceuticals have been approved and, due to patents expiration, many biosimilars are also marketed.
Industrial Challenges of Recombinant Proteins.- Insights on the Formulation of Recombinant Proteins.- Therapeutic Antibody Engineering and Selection Strategies.- Cytokines and Growth Factors.- Hormones, Blood Products and Therapeutic Enzymes.- Advances in Vaccines.- Human Pluripotent Stem Cells: Applications and Challenges for Regenerative Medicine and Disease Modeling.- Addressing the Manufacturing Challenges of Cell-Based Therapies.- Bioprinting Technologies in Tissue Engineering.- Gene Therapy.- The Impact of Pharmacogenomics in Personalized Medicine.