This book constitutes the refereed joint proceedings of the 4th International Workshop on Large-Scale Annotation of Biomedical Data and Expert Label Synthesis, LABELS 2019, the First International Workshop on Hardware Aware Learning for Medical Imaging and Computer Assisted Intervention, HAL-MICCAI 2019, and the Second International Workshop on Correction of Brainshift with Intra-Operative Ultrasound, CuRIOUS 2019, held in conjunction with the 22nd International Conference on Medical Imaging and Computer-Assisted Intervention, MICCAI 2019, in Shenzhen, China, in October 2019.

4th International Workshop on Large-Scale Annotation of Biomedical Data and Expert Label Synthesis (LABELS 2019).- Comparison of active learning strategies applied to lung nodule segmentation in CT scans.- Robust Registration of Statistical Shape Models for Unsupervised Pathology Annotation.- XiangyaDerm: A Clinical Image Dataset of Asian Race for Skin Disease Aided Diagnosis.- Data Augmentation based on Substituting Regional MRI Volume Scores.- Weakly supervised segmentation from extreme points.- Exploring the Relationship between Segmentation Uncertainty, Segmentation Performance and Inter-observer Variability with Probabilistic Networks.- DeepIGeoS-V2: Deep Interactive Segmentation of Multiple Organs from Head and Neck Images with Lightweight CNNs.- The Role of Publicly Available Data in MICCAI Papers from 2014 to 2018.- First International Workshop on Hardware Aware Learning for Medical Imaging and Computer Assisted Intervention (HAL-MICCAI 2019).- Hardware Acceleration of Persistent Homology Computation.- Deep Compressed Pneumonia Detection for Low-Power Embedded Devices.- D3MC: A Reinforcement Learning based Data-driven Dyna Model Compression.- An Analytical Method of Automatic Alignment for Electron Tomography.- Fixed-Point U-Net Quantization for Medical Image Segmentation.- Second International Workshop on Correction of Brainshift with Intra-Operative Ultrasound (CuRIOUS 2019).- Registration of ultrasound volumes based on Euclidean distance transform.- Landmark-based evaluation of a block-matching registration framework on the RESECT pre- and intra-operative brain image data set.- Comparing deep learning strategies and attention mechanisms of discrete registration for multimodal image-guided interventions.