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Pertussis Infection and Vaccines
Advances in Microbiology, Infectious Diseases and Public Health Volume 12
Sofort lieferbar | Lieferzeit: Sofort lieferbar I
ISBN-13:
9783030332495
Veröffentl:
2020
Seiten:
170
Autor:
Giorgio Fedele
Serie:
1183, Advances in Microbiology, Infectious Diseases and Public Health Advances in Experimental Medicine and Biology
eBook Typ:
PDF
eBook Format:
EPUB
Kopierschutz:
1 - PDF Watermark
Sprache:
Englisch
Beschreibung:
Pertussis remains one of the most poorly controlled vaccine-preventable diseases around the globe. Universal vaccination has dramatically reduced its incidence but has failed to bring it completely under control. In recent decades, changes in pertussis epidemiology have been noted, likely related to the use of acellular pertussis vaccines, which in many countries have replaced older-generation, whole-cell pertussis vaccines. Several years after their introduction, it is becoming apparent that immunity conferred by acellular vaccines wanes more rapidly than expected. Unlike whole-cell vaccines, acellular vaccines, while protecting against the disease, do not seem to prevent colonization and transmission. Increasing incidence among adolescents and adults makes them a reservoir for transmission to unimmunized infants, who in turn are at risk of severe disease and death.
How Genomics Is Changing What We Know About the Evolution and Genome of Bordetella pertussis.- Molecular epidemiology of Bordetella pertussis.- Role of Major Toxin Virulence Factors in Pertussis Infection and Disease Pathogenesis.- Functional Programming of Innate Immune Cells in Response to Bordetella pertussis Infection and Vaccination.- Superior B. pertussis Specific CD4+ T-Cell Immunity Imprinted by Natural Infection.- Human Immune Responses to Pertussis Vaccines.- New Pertussis Vaccines: A Need and a Challenge.- Pertussis: Identification, Prevention and Control.- Pertussis in Low and Medium Income Countries: A Pragmatic Approach.- Clinical Findings and Management of Pertussis.- Pertussis Vaccines and Vaccination Strategies. An Ever-Challenging Health Problem.
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