The area of CLM is subject to great and continuous advances, as its pathophysiologic mechanisms are better understood and more therapeutic and surgical options are developed. Consequently, all professionals involved with the diagnosis, treatment and follow up of CLM should be kept up to date with the latest advances on the field, to provide high standard medical care to their patients.

History of Colorectal Liver Metastases (CLM).- How and Why does CLM Occur.- Biological Behaviour of CLM.- Diagnostic Workup.- Staging of CLM.- Prognostic Factors.- Clinical Scoring Systems-. Patient and Treatment Selection.- The impact of Multimodal Team and Strategies.- Evolution of Chemotherapy and Biologicals.- Neoadjuvant.- Conversion.- Adjuvant treatment.- Palliative treatment.- Intra-arterial chemotherapy.- BEADS - chemoembolization.- Immunotherapy and Vaccines.- The role of surgery.- Liver first.- Combined resection.- Staged resection.- Resection + ablation.- Special Techniques - PVE , ALLPS, Torsilli, Vascular Reconstruction.- Parenchymal sparing surgery.- Re-resection.- Liver pedicle lymphadenectomy.-Anatomical, Physiological and Kinetic evaluation of the future liver remnant.- Liver and EHD.- The Issue of Surgical Margins.-Laparoscopic and Robotic Resection.- Navigation and Enhanced reality.- Liver transplantation for CLM.- Ablative Techniques.-SIRT.- External Radiation.- Combined Treatment - MARCELO RIBEIRO.- Follow Up Strategy.- Prognosis and Management of Recurrence.- Experiences in different continents (LIVERMET SURVEY).