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Human Epigenetics: How Science Works
ISBN-13:
9783030229078
Veröffentl:
2019
Seiten:
153
Autor:
Carsten Carlberg
eBook Typ:
PDF
eBook Format:
EPUB
Kopierschutz:
1 - PDF Watermark
Sprache:
Englisch
Beschreibung:
The view "It's all in our genes and we cannot change it" developed in the past 150 years since Gregor Mendel's experiments with flowering pea plants. However, there is a special form of genetics, referred to as epigenetics, which does not involve any change of our genes but regulates how and when they are used. In the cell nucleus our genes are packed into chromatin, which is a complex of histone proteins and genomic DNA, representing the molecular basis of epigenetics. Our environment and lifestyle decisions influence the epigenetics of our cells and organs, i.e. epigenetics changes dynamically throughout our whole life. Thus, we have the chance to change our epigenetics in a positive as well as negative way and are able to prevent the onset of diseases, such a type 2 diabetes or cancer.
Introduction.- Chromatin and gene expression.- DNA methylation.- Histone modifications.- Chromatin modifying proteins and RNAs.- Embryogenesis and cellular differentiation.- Population epigenetics and aging.- Cancer epigenetics.- Neuroepigenetics.- Nutritional epigenetics.- Epigenetics of immune function.- Epigenome-environment interactions and their therapy.
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