This book is a comprehensive review of stereotactic radiosurgery (SRS) and stereotactic body radiation therapy (SBRT): its physics, clinical evidence, indications, and future directions. The utilization of stereotactic radiosurgery (SRS) and stereotactic body radiation therapy (SBRT) is increasing internationally because of several factors. First, it offers patients a local treatment option that has demonstrated effectiveness similar to traditional surgery without the morbidity of general anesthesia and open surgical resection. Second, recent advancements in the quality of scientific evidence supporting a SRS or SBRT-containing approach in patients continues to evolve and demonstrate favorable disease-specific outcomes with little, if any, toxicity in various anatomic disease sites and for various conditions including cancer, benign tumors, and other psychiatric and neurologic conditions. Third, and most provocatively, is the notion that definitive local therapy (i.e. SRS or SBRT) in patients with cancer can boost the immune system to fight cancer in other sites throughout the body. While traditional medical knowledge would suggest that all patients with metastatic cancer are incurable, there is a mounting body of evidence that there is a subset of these patients that can be cured with definitive SRS or SBRT. This volume thus delves into each of these benefits and aspects of treatment, guiding physicians to the best treatment plan for their patients.

Section I: Radiobiology of Radiosurgery and Stereotactic Body Radiation Therapy.- Vascular-Mediated Mechanisms.- Immune-Mediated Mechanisms.- Rationale for Fractionated and Single Session Approaches.- Section II: Intracranial Radiosurgery Technique.- Physics of Radiosurgery.- Leksell Gamma Knife Radiosurgery.- Accuray CyberKnife Robotic Radiosurgery.- Linear Accelerator-Based Radiosurgery.- Fractionated Radiosurgery.- Charged Particle Radiosurgery.- Section III: Intracranial Radiosurgery by Indication.- Brain Metastases.- Pituitary Tumors.- Meningioma.- Vascular Malformations.- Trigeminal Neuralgia.- Movement Disorders and Obsessive Compulsive Disorder.- Glial Tumors.- Pediatric Tumors.- Section IV: Stereotactic Body Radiation Therapy Technique.- Physics of SBRT.- Immobilization.- Motion Management.- Charged Particle SBRT.- Section V: Stereotactic Body Radiation Therapy by Indication.- Primary Lung Cancers.- Lung Metastes.- Spinal Tumors.- Gastrointestinal Cancers.- Prostate Cancer.- Head and Neck Cancer.- Section VI: The Future of Radiosurgery and SBRT.- Patient Selection.- SRS and SBRT Complications and Management.- SRS AND SBRT Integration with Supportive Care.- Targeted Agents and Immunotherapy.- Diagnostic Imaging Advances.- Comparative Effectiveness.