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Polymyxin Antibiotics: From Laboratory Bench to Bedside
ISBN-13:
9783030163730
Veröffentl:
2019
Seiten:
366
Autor:
Jian Li
Serie:
1145, Advances in Experimental Medicine and Biology
eBook Typ:
PDF
eBook Format:
EPUB
Kopierschutz:
1 - PDF Watermark
Sprache:
Englisch
Beschreibung:
This volume is the first-ever complete treatise on polymyxins and presents the most comprehensive and up-to-date reviews of all major research and clinical topics from chemistry, microbiology, pharmacology, clinical use, to drug discovery. All chapters were written by internationally leading researchers and clinicians in the field.
Overview.- Multidrug resistant Gram-negative pathogens: the urgent need for 'old' polymyxins.- Discovery, antibacterial spectrum and chemistry.- Mechanisms of antibacterial activity.- Mechanisms of resistance.- Bioanalysis and stability of polymyxins.- In vitro pharmacodynamics and PK/PD in animals.- Antibacterial susceptibility breakpoints.- Labeling of parenteral products of colistin methanesulfonate.- Meta-analysis of polymyxin use in patients.- Clinical use of colistin.- Clinical use of polymyxin B.- Pharmacokinetics, pharmacodynamics, toxicodynamics and dosing recommendations.- Rational combinations with other antibiotics.- Toxicities in patients: management and mechanisms.- Antiendotoxin effect.- Discovery of novel polymyxin-like antibiotics.- Conclusion.
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